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Examines the nature of mental illness, focusing on the theory of psychiatric genetics. This book presents the viewpoints of investigators, policy analysts, and psychiatric patients. It explores the roles of genes in mental illness and describe various clinical, ethical, and social implications of psychiatric genetics. "Refreshing and informative...describe[s] the new complex research tools, directions and interpretations in a lucid and understandable fashion." - "Lancet", North American edition. "Beautifully crafted...The most significant contribution of this book involves its integration of areas that are not typically considered in genetic overviews." - "American Scientist", 1998. "This book does an extraordinary job of making sense out of the many complex and controversial issues surrounding psychiatric genetics...It is worth the price." - "Journal of Genetic Counseling", Vol 6, No 3, 1997. This collection of essays clearly examines the complex nature of mental illness, focusing on the theory and state of the art of psychiatric genetics. This insightful volume is the first to present the diverse viewpoints of investigators, policy analysts, and psychiatric patients. Contributors explore the roles of genes in mental illness and describe various clinical, ethical, and social implications of psychiatric genetics. Additional discussions include trends in psychiatric genetic research, nature versus nurture in behavioral genetics, basic statistical principles of linkage analysis, and the many social domains relevant to psychiatric genetics.

Mental illness --- Genetic aspects

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Through a comparion of etnographic research in the UK and Brazil, this chapter has examined now changing scientific and medical understandings regarding the origin, genealogical history and patrimony of the so-called Ashkenazi mutations have been diversely taken up and put to use in clinical/research contexts. It has explored the very differing differing differing consequences this can have for the way health care practitioners, scientists, patients and their families engage with and incorporate knowledge about hereditary BRCA mutations into scientific narratives, clinical practices and understandings of clinical/familial risk and identity.

Breast --- Cancer --- Genetic aspects.

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Breast --- Ovaries --- Cancer --- Genetic aspects. --- Cancer --- Genetic aspects.

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Connective tissues --- Diseases --- Genetic aspects.

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Today a new generation of powerful cancer therapeutics targeted against the molecular pathways that produce malignant phenotypes is rapidly emerging. In Cancer Gene Therapy, leading basic and clinical cancer oncologists provide a complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. In their discussions, the authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed. Authoritative and wide ranging, Cancer Gene Therapy offers a comprehensive survey of the molecular basis of cancer gene therapy and demonstrates its enormous potential to take a place in the clinic alongside the current generation of anticancer therapeutics.

Cancer --- Gene therapy. --- Genetic aspects --- Treatment